Netarsudil dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Netarsudil (AR-13324) 是一种有效的选择性 ROCK 抑制剂，对 ROCK2 的 Ki 值为 4.2 nM。

Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2; 11 kinases are inhibited >90% in a panel of 422 kinases, only ROCK1 and ROCK2 (each 93% inhibition) and PKC (delta, 91%, and eta, 93% inhibition); exhibts improved bioavailability, demonstrates an effective and sustained IOP reduction for 24h after dosing; a novel ocular hypotensive agent for the treatment of Gglaucoma.Other Indication Approved.

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Netarsudil hydrochloride (0.04%, 50 ΜL)reduces intraocular pressure (IOP) in normotensive monkey eyes.Netarsudil hydrochloride (0.04%) produces statistically significant lowering of episcleral venous pressure (EVP) in Dutch Belted rabbits. Animal Model:Adult female cynomolgus monkeys (3-5 kg)Dosage:0.04%, 50 μLAdministration:Topically applied to eye Result:Reduces IOP in normotensive monkey eyes.

AR-13324

Cell Cycle/DNA Damage

ROCK

ROCK

Other Indications

Other Disease

1253952-02-1

526.45

C28H29Cl2N3O3

>98% (HPLC)

In Vitro:?DMSO : 5 mg/mL (9.50 mM)

CC1=CC(=C(C=C1)C(=O)OCC2=CC=C(C=C2)C(CN)C(=O)NC3=CC4=C(C=C3)C=NC=C4)C.Cl.Cl

(S)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate dihydrochloride

(-20℃)

With Ice Pack

≥ 2 years